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Flu is expected to flare up in U.S. this winter, raising fears of a 'twindemic'

Health officials are predicting this winter could see an active flu season on top of potential COVID surges. In short, it's a good year to be a respiratory virus. Left: Image of SARS-CoV-2 omicron virus particles (pink) replicating within an infected cell (teal). Right: Image of an inactive H3N2 influenza virus.
Health officials are predicting this winter could see an active flu season on top of potential COVID surges. In short, it's a good year to be a respiratory virus. Left: Image of SARS-CoV-2 omicron virus particles (pink) replicating within an infected cell (teal). Right: Image of an inactive H3N2 influenza virus.

The flu virtually disappeared for two years as the pandemic raged. But influenza appears poised to stage a comeback this year in the U.S., threatening to cause a long-feared "twindemic."

While the flu and the coronavirus are both notoriously unpredictable, there's a good chance COVID cases will surge again this winter, and troubling signs that the flu could return too.

"This could very well be the year in which we see a twindemic," says Dr. William Schaffner, an infectious disease professor at Vanderbilt University. "That is, we have a surge in COVID and simultaneously an increase in influenza. We could have them both affecting our population at the same time."

The strongest indication that the flu could hit the U.S. this winter is what happened during the Southern Hemisphere's winter. Flu returned to some countries, such as Australia, where the respiratory infection started ramping up months earlier than normal, and caused one of the worst flu seasons in recent years.

What happens in the Southern Hemisphere's winter often foreshadows what's going to happen north of the equator.

"If we have a serious influenza season, and if the omicron variants continue to cause principally mild disease, this coming winter could be a much worse flu season than COVID," Schaffner warns.

And the combination of the two viruses could seriously strain the health system, he says. The Centers for Disease Control and Prevention estimates that flu causes between 140,00 and 710,000 hospitalizations annually.

"We should be worried," says Dr. Richard Webby, an infectious disease specialist at St. Jude Children's Research Hospital. "I don't necessarily think it's run-for-the-hills worried. But we need to be worried."

The main reason the flu basically disappeared the last two years was the behavior changes people made to avoid COVID, such as staying home, avoiding public gatherings, wearing masks, and not traveling. That prevented flu viruses from spreading too. But those measures have mostly been abandoned.

"As the community mitigation measures start to roll off around the world and people return to their normal activities, flu has started to circulate around the world," says Dr. Alicia Fry, who leads influenza epidemiology and prevention for the CDC. "We can expect a flu season this year — for sure."

Young kids at especially high risk

The CDC is reporting that the flu is already starting to spread in parts of the south, such as Texas. And experts caution very young kids may be especially at risk this year.

Though COVID-19 generally has been mild for young people, the flu typically poses the biggest threat to both the elderly and children. The main strain of flu that's currently circulating, H3N2, tends to hit the elderly hard. But health experts are also worried about young children who have not been exposed to flu for two years.

"You have the 1-year-olds, the 2-year-olds, and the 3-year-olds who will all be seeing it for the first time, and none of them have any preexisting immunity to influenza," says Dr. Helen Chu, assistant professor of medicine and allergy and infectious diseases and an adjunct assistant professor of epidemiology at the University of Washington.

In fact, the flu does appear to have hit younger people especially hard in Australia.

"We know that schools are really the places where influenza spreads. They're really considered the drivers of transmission," Chu says. "They'll be the spreaders. They will then take it home to the parents. The parents will then take it to the workplace. They'll take it to the grandparents who are in assisted living, nursing home. And then those populations will then get quite sick with the flu."

"I think we're heading into a bad flu season," Chu says.

'Viral interference' could offset the risks

Some experts doubt COVID and flu will hit the country simultaneously because of a phenomenon known as "viral interference," which occurs when infection with one virus reduces the risk of catching another. That's an additional possible reason why flu disappeared the last two years.

"These two viruses may still both occur during the same season, but my gut feeling is they're going to happen sequentially rather than both at the same time," Webby says. "So I'm less concerned about the twindemic."

Nevertheless, Webby and others are urging people to make sure everyone in the family gets a flu shot as soon as possible, especially if the flu season arrives early in the U.S. too. (Most years officials don't start pushing people to get their flu shots until October.)

So far it looks like this year's flu vaccines are a good match with the circulating strains and so should provide effective protection.

But health officials fear fewer people will get flu shots this year than usual because of anti-vaccine sentiment that increased in reaction to COVID vaccinations. Flu vaccine rates are already lagging.

"We are worried that people will not get vaccinated. And influenza vaccine is the best prevention tool that we have," the CDC's Fry says.

Fry also hopes that some of the habits people developed to fight COVID will continue and help blunt the impact of the flu.

"The wild card here is we don't know how many mitigation practices people will use," Fry says. "For example, people now stay home when they're sick instead of going to work. They keep their kids out of school. Schools are strict about not letting kids come to school if their sick. All of these types of things could reduce transmission." Copyright 2022 NPR. To see more, visit https://www.npr.org.

Transcript:

STEVE INSKEEP, HOST:

For the last two years, the flu mostly disappeared. People who isolated to duck COVID also avoided influenza. Did you notice this? Hardly anybody in my family got sick with anything for a while. But what happens this year as so many people are back at work and school unmasked? NPR health correspondent Rob Stein joins us now. Good morning.

ROB STEIN, BYLINE: Good morning, Steve.

INSKEEP: How serious could this year's flu season be?

STEIN: You know, Steve, the first thing I should say is that the flu is notoriously unpredictable, so it's impossible to say precisely what's going to happen. That said, there are signs that the flu's hiatus is ending. And not only does it look like the flu could be back for the first time in three years, there are indications it could be a bad flu season.

INSKEEP: What indications do you mean?

STEIN: The big one is that after disappearing in the Southern Hemisphere for the last two years, the flu came roaring back in some countries south of the equator - in Australia.

INSKEEP: Oh. They've had their winter, so they've had their flu season. We're getting an early sign here. OK. Go on.

STEIN: Exactly. Exactly. And in Australia, in their winter, the flu also hit unusually early. And what happens in the Southern Hemisphere's winter often foreshadows what's going to happen here.

Dr. William Schaffner is a flu specialist at Vanderbilt University.

WILLIAM SCHAFFNER: Clearly, the Southern Hemisphere had a serious influenza season. So if we have a serious influenza season and if the omicron variants continue to cause principally mild disease, this coming winter could be a much worse flu season than COVID.

STEIN: In fact, Steve, the CDC says the flu is already spreading in parts of the south, like Texas.

SCHAFFNER: This could very well be the year in which we see a twindemic (ph). That is, we have a surge in COVID and simultaneously an increase in influenza.

STEIN: And, you know, Steve, when it comes to the flu, it's both the elderly and children doctors worry about most, especially this year.

INSKEEP: Why would doctors especially worry about kids?

STEIN: Well, you know, Steve, the big reason the flu basically vanished the last two years was everything everyone did to fend off COVID - you know, staying home, avoiding other people, you know, wearing masks, not traveling. That prevented flu viruses from spreading, too. And at the same time, the coronavirus may have kind of elbowed the flu out of the way. That helped spare us from an earlier twindemic, but it also means lots of kids have never been exposed to the flu.

I talked about this with Dr. Helen Chu at the University of Washington.

HELEN CHU: Because children haven't seen flu for two years now, you have the 1-year-olds, the 2-year-olds and the 3-year-olds who have - all be seeing it for the first time, and none of them have any preexisting immunity to influenza. So I'm a little worried.

STEIN: The flu does appear to have hit kids especially hard in Australia.

CHU: Older children will get influenza. They will probably not get as sick as the younger children, but they'll be the spreaders. They will then take it home to their parents. The parents will then take it to their workplace. They'll take it to the grandparents who are in assisted living, nursing homes. And then those populations will also get quite sick with the flu.

INSKEEP: A pattern, of course, that we were warned about with the pandemic as well. But I want to note, I was in the other day to get a booster shot, and they said, get a flu vaccine, same time. And so I went ahead and got it - two shots. There are still good flu vaccines, right?

STEIN: Absolutely. Absolutely. So doctors are urging everyone to get a flu shot, which, so far, look like a pretty good match to the flu strains that are spreading the fastest right now.

Here's Dr. Richard Webby at St. Jude's Research - St. Jude Children's Research Hospital.

RICHARD WEBBY: We should be worried. You know, I don't necessarily think it's run-for-the-hills worried, but we need to be worried enough to go out and get the vaccine. And my suggestion is get the vaccine probably early this year.

STEIN: Like you, like, get it now, Webby says. But experts are worried about that, too, because vaccination rates are down because of all the anti-vaccination sentiments stirred up by the pandemic.

INSKEEP: Well, what else can people do?

STEIN: The hope is that certain aspects of our new normal could help.

I talked about this with Alicia Fry at the CDC.

ALICIA FRY: The wild card here is we don't know how many mitigation practices people will use. For example, people now stay home when they're sick instead of going to work. If they keep their kids out of school, if schools are stricter about not letting kids come to school if they're sick - all of these types of things could reduce the transmission.

STEIN: And could help prevent, or at least blunt, a twindemic.

INSKEEP: NPR's Rob Stein, thanks.

STEIN: You bet, Steve. Transcript provided by NPR, Copyright NPR.